alpha,2-pyridyl-2,8-bis(trifluoromethyl)quinoline-4-acetonitrile
- Name alpha,2-pyridyl-2,8-bis(trifluoromethyl)quinoline-4-acetonitrile
- CAS 83012-12-8
- Purity 99%
Product Details
Top Quality Chinese Factory supply 83012-12-8 alpha,2-pyridyl-2,8-bis(trifluoromethyl)quinoline-4-acetonitrile
- Molecular Formula: C18H9 F6 N3
- Molecular Weight: 381.28
- Vapor Pressure: 3.26E-07mmHg at 25°C
- Boiling Point: 418.5°C at 760 mmHg
- PKA: 1.96±0.19(Predicted)
- Flash Point: 206.9°C
- PSA： 49.57000
- Density: 1.427g/cm3
- LogP: 5.32288
alpha,2-pyridyl-2,8-bis(trifluoromethyl)quinoline-4-acetonitrile(Cas 83012-12-8) Usage
InChI:InChI=1/C18H9F6N3/c19-17(20,21)13-5-3-4-10-11(8-15(18(22,23)24)27-16(10)13)12(9-25)14-6-1-2-7-26-14/h1-8,12H
83012-12-8 Relevant articles
ONE POT SYNTHESIS OF [2, 8-BIS (TRIFLUOROMETHYL)-4- QUINOLINYL]2-PYRIDINYLMETHANONE, A MEFLOQUINE INTERMEDIATE
-
, (2008/06/13)
The present invention provides a simple ...
A straightforward mid high yielding synthesis of mefloquine - II
Adam, Solange
, p. 7609 - 7614 (2007/10/02)
A new practical and high yielding synthe...
83012-12-8 Process route
-
-
2739-97-1
pyridine-2-acetonitrile
-
-
83012-13-9
2,8-bis-(trifluoromethyl)-4-chloro-quinoline
-
-
83012-12-8
α-(2-Pyridyl)-2,8-bis(trifluoromethyl)-4-quinolylacetonitrile
| Conditions | Yield |
|---|---|
|
With
sodium hydride;
Yield given. Multistep reaction;
1.) toluene, DMF, 0 - 5 deg C, 1 h, 2.) toluene, DMF, 5 - 10 deg C, 2 h;
|
|
|
With
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride;
In
water;
|
14.52 gm (99%)
|
-
-
35853-41-9
2,8-bis(trifluoromethyl)quinolin-4-ol
-
-
83012-12-8
α-(2-Pyridyl)-2,8-bis(trifluoromethyl)-4-quinolylacetonitrile
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: 85 percent / POCl3
/ 2 h / 110 °C
2: 1.) NaH / 1.) toluene, DMF, 0 - 5 deg C, 1 h, 2.) toluene, DMF, 5 - 10 deg C, 2 h
With
sodium hydride; trichlorophosphate;
|
83012-12-8 Upstream products
-
2739-97-1
pyridine-2-acetonitrile
-
83012-13-9
2,8-bis-(trifluoromethyl)-4-chloro-quinoline
-
35853-41-9
2,8-bis(trifluoromethyl)quinolin-4-ol
83012-12-8 Downstream products
-
35853-55-5
[2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone
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