(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
- Name(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
- CAS22446-37-3
- Purity99%
Product Details
Manufacturers supply cost-effective and customizable (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER 22446-37-3
- Molecular Formula:C9H10O3
- Molecular Weight:166.177
- Vapor Pressure:0.00692mmHg at 25°C
- Melting Point:122-124℃
- Refractive Index:1.539
- Boiling Point:261.9 °C at 760 mmHg
- PKA:9.55±0.30(Predicted)
- Flash Point:110 °C
- PSA：46.53000
- Density:1.181g/cm3
- LogP:1.10770
(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER(Cas 22446-37-3) Usage
|
Synthesis Reference(s) |
Synthetic Communications, 24, p. 2743, 1994 DOI: 10.1080/00397919408010590 |
InChI:InChI=1/C9H10O3/c1-12-9(11)6-7-4-2-3-5-8(7)10/h2-5,10H,6H2,1H3
22446-37-3 Relevant articles
-
Levine,Eble,Fischbach
, p. 1930 (1948)
-
Regioselective Synthesis of Benzofuranones and Benzofurans
Zhang, Xiaojie,Beaudry, Christopher M.
, p. 6931 - 6936 (2021)
Reaction of 3-hydroxy-2-pyrones with nit...
Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid
Krogsgaard-Larsen, Niels,Delgar, Claudia G.,Koch, Karina,Brown, Patricia M. G. E.,M?ller, Charlotte,Han, Liwei,Huynh, Tri H. V.,Hansen, Stinne W.,Nielsen, Birgitte,Bowie, Derek,Pickering, Darryl S.,Kastrup, Jette Sandholm,Frydenvang, Karla,Bunch, Lennart
, p. 441 - 457 (2017)
Ionotropic glutamate receptor antagonist...
Copper-catalyzed formal [1 + 2 + 2]-annulation of alkyne-tethered diazoacetates and pyridines: Access to polycyclic indolizines
Dong, Shanliang,Hu, Wenhao,Huang, Jingjing,Qiu, Lihua,Sha, Hongkai,Xu, Xinfang
, p. 1926 - 1932 (2020)
A copper-catalyzed formal [1 + 2 + 2]-an...
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach
Lorthiois, Edwige,Roache, James,Barnes-Seeman, David,Altmann, Eva,Hassiepen, Ulrich,Turner, Gordon,Duvadie, Rohit,Hornak, Viktor,Karki, Rajeshri G.,Schiering, Nikolaus,Weihofen, Wilhelm A.,Perruccio, Francesca,Calhoun, Amy,Fazal, Tanzina,Dedic, Darija,Durand, Corinne,Dussauge, Solene,Fettis, Kamal,Tritsch, Fabien,Dentel, Celine,Druet, Adelaide,Liu, Donglei,Kirman, Louise,Lachal, Julie,Namoto, Kenji,Bevan, Douglas,Mo, Rose,Monnet, Gabriela,Muller, Lionel,Zessis, Richard,Huang, Xueming,Lindsley, Loren,Currie, Treeve,Chiu, Yu-Hsin,Fridrich, Cary,Delgado, Peter,Wang, Shuangxi,Hollis-Symynkywicz, Micah,Berghausen, Joerg,Williams, Eric,Liu, Hong,Liang, Guiqing,Kim, Hyungchul,Hoffmann, Peter,Hein, Andreas,Ramage, Paul,D'arcy, Allan,Harlfinger, Stefanie,Renatus, Martin,Ruedisser, Simon,Feldman, David,Elliott, Jason,Sedrani, Richard,Maibaum, Juergen,Adams, Christopher M.
, p. 8088 - 8113 (2020)
The serine protease factor XI (FXI) is a...
Preparation method of carboxylic ester compound
-
Paragraph 0051-0052, (2021/03/30)
The invention relates to a preparation m...
Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite
Cheng, Xionglve,Jiang, Gangzhong,Li, Xingxing,Tao, Suyan,Wan, Xiaobing,Zhao, Yanwei,Zheng, Yonggao
supporting information, p. 2713 - 2718 (2021/06/25)
In this work, the green esterification o...
Insights into Ruthenium(II/IV)-Catalyzed Distal C?H Oxygenation by Weak Coordination
Bu, Qingqing,Kuniyil, Rositha,Shen, Zhigao,Gońka, El?bieta,Ackermann, Lutz
supporting information, p. 16450 - 16454 (2020/11/02)
C?H hydroxylation of aryl acetamides and...
22446-37-3 Process route
-
-
101-41-7
benzeneacetic acid methyl ester
-
-
14199-15-6
Methyl 4-hydroxyphenylacetate
-
-
22446-37-3
methyl (2-hydroxyphenyl)acetate
-
-
42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester
| Conditions | Yield |
|---|---|
|
With
sulfuric acid; dihydrogen peroxide; iron(III); benzene-1,2-diol;
In
water;
at 25 ℃;
Product distribution;
further mediators investigated;
|
-
-
496-64-0
3-hydroxy-2-pyrone
-
-
34805-49-7
methyl 3-nitrobut-3-enoate
-
-
553-86-6
benzofuran-2(3H)-one
-
-
22446-37-3
methyl (2-hydroxyphenyl)acetate
| Conditions | Yield |
|---|---|
|
With
aluminum (III) chloride; 2,6-di-tert-butyl-4-methyl-phenol;
In
1,2-dichloro-benzene;
at 120 ℃;
for 2h;
Inert atmosphere;
|
53% 15% |
|
With
2,6-di-tert-butyl-4-methyl-phenol; dimethylaluminum chloride; trifluoroacetic acid;
In
1,2-dichloro-benzene;
at 100 ℃;
for 2.5h;
Inert atmosphere;
|
30% 29% |
22446-37-3 Upstream products
-
186581-53-3
diazomethane
-
614-75-5
2-Hydroxyphenylacetic acid
-
67-56-1
methanol
-
2065-23-8
methyl 2-phenoxyacetate
22446-37-3 Downstream products
-
55842-25-6
α-Phenyl-(o-carbomethoxymethyl)-phenoxy-acetat
-
153623-45-1
Methyl <2-(tetrahydropyranyloxy)phenyl>acetate
-
103474-02-8
methyl 2-(2-phenoxyphenyl)acetate
-
76251-01-9
methyl 2-(3,5-dibromo-2-hydroxyphenyl)acetate
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